13 Tips to Help Manage Side Effects from Aromatase Inhibitors

Fulvestrant is thought to act by downregulating ER, and its activity in AI-resistant tumour suggests that even at low oestradiol concentrations the ER is active on gene promoters. By comparison with the multiple potential interactions after tamoxifen binding and translocation of the ER, the action of AIs appears relatively simple. It is presumed that oestradiol levels are reduced to the extent that receptor dimerization and translocation do not take place to any appreciable extent. Thus, in the oestrogen responsive tumour cell, growth is abrogated. Differences in mechanisms of action of AIs and tamoxifen are exemplified by changes in transcription of the oestrogen-induced genes PgR and pS2.

Like with any supplement, side effects are possible, but with natural anti-aromatase support, your chances of experiencing any uncomfortable or unpleasant side effects are slim. Most people can safely experience the benefits of these supplements. The authors also observed a similar result with the main constituents of Cannabis sativa, such as tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN). Anastrozole and letrozole are triazolic derivatives and therefore have a nitrogen-containing heterocyclic ring. Many azole compounds can be inhibitors or inducers of cytochrome P450 and, consequently, interfere with the metabolism of other substances depending on the monoamino oxigenase system. Lipophilic compounds containing heterocyclic nitrogen, such as phenylpyridines and phenylimidazoles, fit this profile (22,23).

Inhibitory mechanism of AIs

• Luteolin is a flavonoid that directly inhibits aromatase production in males.
• Its non-specific inhibition of P450 enzymes, other than aromatase, caused significant side effects.
• Men taking this medication should talk to their providers about the potential for birth defects and the need for contraception.
• Studies show people who take aromatase inhibitors after breast cancer surgery remain free of breast cancer for five or more years after treatment.
• This phenomenon is responsible for higher plasma concentrations of the drug and greater individual variability.

Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions. The straight answer is that there is no specific age when you should begin taking these supplements. Scientific opinion ranges from everybody over 60 to when you need them. At SuperSmart, we prefer a conservative approach, whereby we recommend starting to take these supplements when you begin to experience a hormonal imbalance. We hear about radiation, about chemo, but about that (Arimidex®), nobody talks about it…For me, I thought, I did enough. On TV even, nobody talks about that…I think people talking about chemo, about radiation, and they have to tell people about Arimidex…But you don’t hear about it.

As this is an emerging topic with limited literature and a paucity of studies, many articles found provided background rather than specific information on our research topic. In patients with advanced breast cancer who progress after a response to tamoxifen, simply stopping tamoxifen can lead to tumour remission, suggesting that tamoxifen may be acting as an agonist 28. Tamoxifen may become an agonist for MCF-7 cells growing in nude mice 29,30. However, when these tumours are retransplanted into new mice tamoxifen treatment stimulates growth. In vitro, cells from tamoxifen-resistant human pleural effusions have been shown to be growth stimulated by tamoxifen. Inhibition of growth can be demonstrated by additional fulvestrant, suggesting tamoxifen agonist activity occurs via ER pathways, as expected 31.

Post Cycle Therapy (PCT)

Most cases of drug induced lupus typically occur in patients with history of personal or family photosensitivity and it has been demonstrated that most of the culprit drugs usually cause photosensitivity reactions 45. Aromatase inhibition is an important treatment strategy for estrogen-dependent breast cancer in postmenopausal women, and red wine may offer a natural form of aromatase blockade. This benefit occurs in red but not white wine, suggesting that it involves some of the specific polyphenols and other constituents of red wine, which is produced using grape skins and pits as well as the fruit.

When considering CYP2A6, drugs such as valproic acid, selegiline and isoniazid may inhibit the activity of this isoform. On the other hand, carbamazepine, phenobarbital, phenytoin, and clonazepam may induce CYP2A6 (50,52). In addition, minor alkaloids present in tobacco can also inhibit CYP2A6 (53,54). Therefore, inducers and inhibitors of CYP2A6 could influence the pharmacokinetic profile of letrozole. The major morphological characteristics of SCLE are annular, non-scarring, papulosquamous or psoriasiform plaques with distribution mainly to the sunlight exposed areas of the body 13.

Flow cytometric analysis of DNA content was based on the acquisition of events in a Becton Dickinson FACSCalibur (San Jose, CA, U.S.A) equipped with CELLQuest Pro software. In order to investigate the morphological changes induced by inhibitors 3a and 4a in MCF-7aro cells, cells were cultured with or without the compounds and examined by phase contrast microscopy (Figure 2). The untreated control cells (medium with 1 nM T) did not show any morphological alterations during the different incubation periods. After 24 hr incubation with the different concentrations of the two inhibitors no significant differences in cell and nuclear morphology were observed.

The most important parts of flavones and isoflavones based on the previous studies, were also utilized in molecular library design(12). As a bonus, lifting weights does make your body produce more testosterone. I’m going to wrap this section by pasting the title of an aromatase study published in Frontiers in Endocrinology in 2020…. Selenium is a “best kept secret” situation for inhibiting aromatase, because it hasn’t been well researched for its impacts on testosterone. In theory, you can get all the benefits you need from just eating a ton of celery. Discover what causes these symptoms and how to reduce them naturally.

They are used regularly to treat hormone imbalances, making them a safe and Steroids natural supplement to add to your diet. On the other hand, the American Society of Clinical Oncology recommends anti-aromatase supplements and medications as part of hormonal therapy after breast cancer surgery for ten years in postmenopausal women. Once an AHT was recommended, most women described an unquestioning initial acceptance of it. A woman with a chronic disease that required ongoing physician care remarked, “Whatever the doctor says, whatever any of the medical people said, that’s it.